Pesquisa | BVS IEC

1.

LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation.

Guy, Clifford; Mitrea, Diana M; Chou, Po-Chien; Temirov, Jamshid; Vignali, Kate M; Liu, Xueyan; Zhang, Hui; Kriwacki, Richard; Bruchez, Marcel P; Watkins, Simon C; Workman, Creg J; Vignali, Dario A A.

Nat Immunol ; 23(5): 757-767, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35437325

2.

LC3-Associated Endocytosis Facilitates ß-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Heckmann, Bradlee L; Teubner, Brett J W; Tummers, Bart; Boada-Romero, Emilio; Harris, Lacie; Yang, Mao; Guy, Clifford S; Zakharenko, Stanislav S; Green, Douglas R.

Cell ; 178(3): 536-551.e14, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31257024

3.

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.

Cunha, Larissa D; Yang, Mao; Carter, Robert; Guy, Clifford; Harris, Lacie; Crawford, Jeremy C; Quarato, Giovanni; Boada-Romero, Emilio; Kalkavan, Halime; Johnson, Michael D L; Natarajan, Sivaraman; Turnis, Meghan E; Finkelstein, David; Opferman, Joseph T; Gawad, Charles; Green, Douglas R.

Cell ; 175(2): 429-441.e16, 2018 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-30245008

4.

LC3-Associated Endocytosis Facilitates ß-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Heckmann, Bradlee L; Teubner, Brett J W; Tummers, Bart; Boada-Romero, Emilio; Harris, Lacie; Yang, Mao; Guy, Clifford S; Zakharenko, Stanislav S; Green, Douglas R.

Cell ; 183(6): 1733-1734, 2020 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-33306957

5.

Localization of a TORC1-eIF4F translation complex during CD8⁺ T cell activation drives divergent cell fate.

Liedmann, Swantje; Liu, Xueyan; Guy, Clifford S; Crawford, Jeremy Chase; Rodriguez, Diego A; Kuzuoglu-Öztürk, Duygu; Guo, Ao; Verbist, Katherine C; Temirov, Jamshid; Chen, Mark J; Ruggero, Davide; Zhang, Hui; Thomas, Paul G; Green, Douglas R.

Mol Cell ; 82(13): 2401-2414.e9, 2022 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-35597236

6.

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.

Tummers, Bart; Mari, Luigi; Guy, Clifford S; Heckmann, Bradlee L; Rodriguez, Diego A; Rühl, Sebastian; Moretti, Julien; Crawford, Jeremy Chase; Fitzgerald, Patrick; Kanneganti, Thirumala-Devi; Janke, Laura J; Pelletier, Stephane; Blander, J Magarian; Green, Douglas R.

Immunity ; 52(6): 994-1006.e8, 2020 06 16.

Artigo em Inglês | MEDLINE | ID: mdl-32428502

7.

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

Malik, Ankit; Sharma, Deepika; Malireddi, R K Subbarao; Guy, Clifford S; Chang, Ti-Cheng; Olsen, Scott R; Neale, Geoffrey; Vogel, Peter; Kanneganti, Thirumala-Devi.

Immunity ; 49(3): 515-530.e5, 2018 09 18.

Artigo em Inglês | MEDLINE | ID: mdl-30231985

8.

Metabolic control of T_FH cells and humoral immunity by phosphatidylethanolamine.

Fu, Guotong; Guy, Clifford S; Chapman, Nicole M; Palacios, Gustavo; Wei, Jun; Zhou, Peipei; Long, Lingyun; Wang, Yong-Dong; Qian, Chenxi; Dhungana, Yogesh; Huang, Hongling; Kc, Anil; Shi, Hao; Rankin, Sherri; Brown, Scott A; Johnson, Amanda; Wakefield, Randall; Robinson, Camenzind G; Liu, Xueyan; Sheyn, Anthony; Yu, Jiyang; Jackowski, Suzanne; Chi, Hongbo.

Nature ; 595(7869): 724-729, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34234346

9.

Exuberant fibroblast activity compromises lung function via ADAMTS4.

Boyd, David F; Allen, E Kaitlynn; Randolph, Adrienne G; Guo, Xi-Zhi J; Weng, Yunceng; Sanders, Catherine J; Bajracharya, Resha; Lee, Natalie K; Guy, Clifford S; Vogel, Peter; Guan, Wenda; Li, Yimin; Liu, Xiaoqing; Novak, Tanya; Newhams, Margaret M; Fabrizio, Thomas P; Wohlgemuth, Nicholas; Mourani, Peter M; Wight, Thomas N; Schultz-Cherry, Stacey; Cormier, Stephania A; Shaw-Saliba, Kathryn; Pekosz, Andrew; Rothman, Richard E; Chen, Kuan-Fu; Yang, Zifeng; Webby, Richard J; Zhong, Nanshan; Crawford, Jeremy Chase; Thomas, Paul G.

Nature ; 587(7834): 466-471, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-33116313

10.

Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4.

Boyd, David F; Allen, E Kaitlynn; Randolph, Adrienne G; Guo, Xi-Zhi J; Weng, Yunceng; Sanders, Catherine J; Bajracharya, Resha; Lee, Natalie K; Guy, Clifford S; Vogel, Peter; Guan, Wenda; Li, Yimin; Liu, Xiaoqing; Novak, Tanya; Newhams, Margaret M; Fabrizio, Thomas P; Wohlgemuth, Nicholas; Mourani, Peter M; Wight, Thomas N; Schultz-Cherry, Stacey; Cormier, Stephania A; Shaw-Saliba, Kathryn; Pekosz, Andrew; Rothman, Richard E; Chen, Kuan-Fu; Yang, Zifeng; Webby, Richard J; Zhong, Nanshan; Crawford, Jeremy Chase; Thomas, Paul G.

Nature ; 588(7836): E5, 2020 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-33208953

11.

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

Guy, Clifford S; Vignali, Kate M; Temirov, Jamshid; Bettini, Matthew L; Overacre, Abigail E; Smeltzer, Matthew; Zhang, Hui; Huppa, Johannes B; Tsai, Yu-Hwai; Lobry, Camille; Xie, Jianming; Dempsey, Peter J; Crawford, Howard C; Aifantis, Iannis; Davis, Mark M; Vignali, Dario A A.

Nat Immunol ; 14(3): 262-70, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23377202

12.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Samir, Parimal; Kesavardhana, Sannula; Patmore, Deanna M; Gingras, Sebastien; Malireddi, R K Subbarao; Karki, Rajendra; Guy, Clifford S; Briard, Benoit; Place, David E; Bhattacharya, Anannya; Sharma, Bhesh Raj; Nourse, Amanda; King, Sharon V; Pitre, Aaron; Burton, Amanda R; Pelletier, Stephane; Gilbertson, Richard J; Kanneganti, Thirumala-Devi.

Nature ; 573(7775): 590-594, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31511697

13.

The composition and signaling of the IL-35 receptor are unconventional.

Collison, Lauren W; Delgoffe, Greg M; Guy, Clifford S; Vignali, Kate M; Chaturvedi, Vandana; Fairweather, DeLisa; Satoskar, Abhay R; Garcia, K Christopher; Hunter, Christopher A; Drake, Charles G; Murray, Peter J; Vignali, Dario A A.

Nat Immunol ; 13(3): 290-9, 2012 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-22306691

14.

Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method.

Wang, Yaqiu; Pandian, Nagakannan; Han, Joo-Hui; Sundaram, Balamurugan; Lee, SangJoon; Karki, Rajendra; Guy, Clifford S; Kanneganti, Thirumala-Devi.

Cell Mol Life Sci ; 79(10): 531, 2022 Sep 28.

Artigo em Inglês | MEDLINE | ID: mdl-36169732

15.

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

Place, David E; Briard, Benoit; Samir, Parimal; Karki, Rajendra; Bhattacharya, Anannya; Guy, Clifford S; Peters, Jennifer L; Frase, Sharon; Vogel, Peter; Neale, Geoffrey; Yamamoto, Masahiro; Kanneganti, Thirumala-Devi.

PLoS Pathog ; 16(3): e1008364, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32150572

16.

Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes.

Shi, Lewis Zhichang; Saravia, Jordy; Zeng, Hu; Kalupahana, Nishan S; Guy, Clifford S; Neale, Geoffrey; Chi, Hongbo.

Proc Natl Acad Sci U S A ; 114(1): E67-E74, 2017 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-27994150

17.

Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.

Kuliyev, Emin; Gingras, Sebastien; Guy, Clifford S; Howell, Sherie; Vogel, Peter; Pelletier, Stephane.

J Neurosci ; 38(10): 2615-2630, 2018 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-29437892

18.

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Sharma, Deepika; Malik, Ankit; Guy, Clifford S; Karki, Rajendra; Vogel, Peter; Kanneganti, Thirumala-Devi.

Gastroenterology ; 154(4): 948-964.e8, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29203393

19.

Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.

Bettini, Matthew L; Chou, Po-Chein; Guy, Clifford S; Lee, Thomas; Vignali, Kate M; Vignali, Dario A A.

J Immunol ; 199(5): 1555-1560, 2017 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-28733484

20.

Membrane association of the CD3Îµ signaling domain is required for optimal T cell development and function.

Bettini, Matthew L; Guy, Clifford; Dash, Pradyot; Vignali, Kate M; Hamm, David E; Dobbins, Jessica; Gagnon, Etienne; Thomas, Paul G; Wucherpfennig, Kai W; Vignali, Dario A A.

J Immunol ; 193(1): 258-67, 2014 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-24899501

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LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation.

LC3-Associated Endocytosis Facilitates ß-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.

LC3-Associated Endocytosis Facilitates ß-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Localization of a TORC1-eIF4F translation complex during CD8⁺ T cell activation drives divergent cell fate.

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

Metabolic control of T_FH cells and humoral immunity by phosphatidylethanolamine.

Exuberant fibroblast activity compromises lung function via ADAMTS4.

Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4.

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

The composition and signaling of the IL-35 receptor are unconventional.

Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method.

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes.

Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.

Membrane association of the CD3Îµ signaling domain is required for optimal T cell development and function.